Publications (since 2000)

Original articles:

  • Ramsey, H., Klaus, C., Pilat, N., Gattringer, M., Baranyi, U., Hock, K., Schwaiger, E., Wrba, F., and Wekerle, T. Anti-LFA-1 and rapamycin overcome costimulation blockade-resistant rejection in sensitized bone marrow recipients. Am J Transplant (revision requested) (2011).
  • Schwaiger, E. , Klaus, C., Matheeussen, V., Baranyi, U., Pilat, N., Ramsey, H., Korom, S., De Meester, I., and Wekerle, T. Dipeptidyl peptidase IV (DPPIV/CD26) inhibition does not improve engraftment of unfractionated syngeneic or allogeneic bone marrow after non-myeloablative conditioning. Exp Hematol (revision requested) (2011).
  • Kristo, I., Wilfingseder, J., Kainz, A., Marschalek, J., Wekerle, T., Mühlbacher, F., Oberbauer, R., and Bodingbauer, M. Effect of intraportal infusion of tacrolimus on ischemic reperfusion injury in orthotopic liver transplantation: A randomised controlled trial. Transpl Int 24:912-9 (2011).
  • Pilat, N., Klaus, C., Gattringer, M., Jaeckel, E., Wrba, F., Golshayan, D., Baranyi, U., and Wekerle, T. Therapeutic efficacy of polyclonal Tregs does not require rapamycin in a low-dose irradiation bone marrow transplantation model. Transplantation 92:280-8 (2011).
  • Baranyi, U., Gattringer, M., Boehm, A., Marth, K., Focke-Tejkl, M., Bohle, B., Blatt, K., Valent, P., Valenta, R., and Wekerle, T. Expression of a major plant allergen as membrane-anchored and secreted protein in human cells with preserved T cell and B cell epitopes. Int Arch Allergy Immunol 156:259-66 (2011).
  • Nierlich, P., Klaus, C., Bigenzahn, S., Pilat, N., Koporc, Z., Pree, I., Baranyi, U., Taniguchi, M., Muehlbacher, F., and Wekerle, T. The role of natural killer T cells in costimulation blockade-based mixed chimerism. Transpl Int 23:1179-89 (2010).
  • Vincenti, F., Blancho, G., Durrbach, A., Friend, P., Grinyo, J., Halloran, P. F., Klempnauer, J., Lang, P., Larsen, C. P., Muehlbacher, F., Nashan, B., Soulillou, J. P., Vanrenterghem, Y., Wekerle, T., Agarwal, M., Gujrathi, S., Shen, J., Shi, R., Townsend, R., and Charpentier, B. Five-year safety and efficacy of belatacept in renal transplantation. J Am Soc Nephrol 21:1587-96 (2010).
  • Muller, Y. D. , Mai, G., Morel, P., Serre-Beinier, V., Gonelle-Gispert, C., Yung, G. P., Ehirchiou, D., Wyss, J. C., Bigenzahn, S., Irla, M., Heusser, C., Golshayan, D., Seebach, J. D., Wekerle, T. *, Buhler, L. *; *co-senior authors. Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation. PLoS One 5:e10352 (2010).
  • Pilat, N., Baranyi, U., Klaus, C., Jaeckel, E., Mpofu, N., Wrba, F., Golshayan, D., Muehlbacher, F., and Wekerle, T. Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioning. Am J Transplant 10:751-62 (2010).
  • Misof, B. M. , Bodingbauer, M., Roschger, P., Wekerle, T., Pakrah, B., Haas, M., Kainz, A., Oberbauer, R., Muehlbacher, F., and Klaushofer, K. Short-term effects of high dose zoledronic acid treatment on bone mineralization density distribution after orthotopic liver transplantation. Calcif Tissue Int 83:167-75 (2008).
  • Koporc, Z., Pilat, N., Nierlich, P., Blaha, P., Bigenzahn, S., Pree, I., Selzer, E., Sykes, M., Muehlbacher, F., and Wekerle, T. Murine mobilized peripheral blood stem cells have a lower capacity than bone marrow to induce mixed chimerism and tolerance. Am J Transplant 8:2025-36 (2008).
  • Fehr, T., Wang, S., Haspot, F., Kurtz, J., Blaha, P., Hogan, T., Chittenden, M., Wekerle, T., and Sykes, M. Rapid deletional peripheral CD8 T cell tolerance induced by allogeneic bone marrow: role of donor class II MHC and B cells. J Immunol 181:4371-80 (2008).
  • Baranyi, U., Linhart, B., Pilat, N., Gattringer, M., Bagley, J., Muehlbacher, F., Iacomini, J., Valenta, R., and Wekerle, T. Tolerization of a type I allergic immune response through transplantation of genetically modified hematopoietic stem cells. J Immunol 180:8168–8175 (2008).
  • Bodingbauer, M., Wekerle, T., Pakrah, B., Roschger, P., Peck-Radosavljevic, M., Silberhumer, G., Grampp, S., Rockenschaub, S., Berlakovich, G., Steininger, R., Klaushofer, K., Oberbauer, R., and Muehlbacher, F. Prophylactic bisphosphonate treatment prevents bone fractures after liver transplantation. Am J Transplant 7:1763-9 (2007).
  • Silberhumer, G., Pokorny, H., Hetz, H., Herkner, H., Rasoul-Rockenschaub, S.,  Soliman, T., Wekerle, T. , Berlakovich, G., Steininger, R., and Muehlbacher, F. Combination of extended donor criteria and changes in the model for end-stage liver disease score predict patient survival and primary dysfunction in liver transplantation: A retrospective analysis. Transplantation 83:588-92 (2007).
  • Pree, I. *, Bigenzahn, S. *, Fuchs, D., Koporc, Z., Nierlich, P., Winkler, C., Brandacher, G., Sykes, M., Muehlbacher, F., Langer, F., and Wekerle, T. *contributed equally. CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of indoleamine-2,3-dioxygenase. Transplantation 83:663-7 (2007).
  • Linhart, B., Bigenzahn, S., Hartl, A., Lupinek, C., Thalhamer, J., Valenta, R., and Wekerle, T. Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy. J Immunol 178:3924-31 (2007).
  • Bodingbauer, M., Pakrah, B., Steininger, R., Berlakovich, G., Rockenschaub, S., Wekerle, T., and Muehlbacher, F. The advantage of allocating kidneys from old cadaveric donors to old recipients: a single-center experience. Clin Transplant 20:471-5 (2006).
  • Koporc, Z., Bigenzahn, S., Blaha, P., Fariborz, E., Selzer, E., Sykes, M., Muehlbacher, F., and Wekerle, T. Induction of mixed chimerism through transplantation of CD45-congenic mobilized peripheral blood stem cells after nonmyeloablative irradiation. Biol Blood Marrow Transplant 12:284-92 (2006).
  • Perco*, P., Blaha*, P., Kainz, A., Mayer, B., Hauser, P., Wekerle, T., and Oberbauer, R. *co-first authors. Molecular signature of mice T lymphocytes following tolerance induction by allogeneic BMT and CD40-CD40L costimulation blockade. Transpl Int 19:146-57 (2006).
  • Fehr, T., Takeuchi, Y., Kurtz, J., Wekerle, T., and Sykes, M. Early regulation of CD8 T cell alloreactivity by CD4+CD25- T cells in recipients of anti-CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor-reactive CD8+ T cells, precluding a role for sustained regulation. Eur J Immunol 35:2679-90 (2005).
  • Vincenti, F. , Larsen, C., Durrbach, A., Wekerle, T., Nashan, B., Blancho, G., Lang, P., Grinyo, J., Halloran, P. F., Solez, K., Hagerty, D., Levy, E., Zhou, W., Natarajan, K., and Charpentier, B. for the belatacept study group. Costimulation blockade with belatacept in renal transplantation. N Engl J Med 353:770-81 (2005).
  • Blaha, P., Bigenzahn, S., Koporc, Z., Sykes, M., Muehlbacher, F., and Wekerle, T. Short-term immunosuppression facilitates induction of mixed chimerism and tolerance after BMT without cytoreductive conditioning. Transplantation 80:237-43 (2005).
  • Bucher, P., Mai, G., Morel, P., Mathe, Z., Bosco, D., Pernin, N., Wekerle, T., Berney, T., and Buhler, L. H. Transplantation of discordant xenogeneic islets using repeated therapy with anti-CD154. Transplantation 79:1545-52 (2005).
  • Bigenzahn, S., Blaha, P., Koporc, Z., Pree, I., Selzer, E., Bergmeister, H., Wrba, F., Heusser, C., Wagner, K., Muehlbacher, F., and Wekerle, T. The role of non-deletional tolerance mechanisms in a murine model of mixed chimerism with costimulation blockade. Am J Transplant 5:1237-47 (2005).
  • Mai, G., Bucher, P., Morel, P., Mei, J., Bosco, D., Andres, A., Mathe, Z., Wekerle, T., Berney, T., and Buhler, L. H. Anti-CD154 mAb treatment but not recipient CD154 deficiency leads to long-term survival of xenogeneic islet grafts. Am J Transplant 5:1021-31 (2005).
  • Mai, G., Bucher, P., Morel, P., Mei, J., Bosco, D., Andres, A., Mathe, Z., Wekerle, T., Berney, T., and Buhler, L. H. Role of CD40-CD154 pathway in the rejection of concordant and discordant xenogeneic islets. Transplant Proc 37:460-2 (2005).
  • Andres, A., Toso, C., Morel, P., Bosco, D., Bucher, P., Oberholzer, J., Mathe, Z., Mai, G., Wekerle, T., Berney, T., and Buhler, L. H. Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation. Transplant Proc 37:463-5 (2005).
  • Andres, A., Toso, C., Morel, P., Bosco, D., Bucher, P., Oberholzer, J., Mathe, Z., Mai, G., Wekerle, T., Berney, T., and Buhler, L. Macrophage depletion prolongs discordant but not concordant islet xenograft survival. Transplantation 79:543-9 (2005).
  • Birsan, T., Loinig, C., Bodingbauer, M., Wekerle, T., Rockenschaub, S., Berlakovich, G., Soliman, T., Muehlbacher, F., and Steininger, R. Comparison between C0 and C2 monitoring in de novo renal transplant recipients: Retrospective analysis of a single center experience. Transplantation 78:1787-91 (2004).
  • Takeuchi, Y. , Ito, H., Kurtz, J., Wekerle, T., Ho, L., and Sykes, M. Earlier low-dose TBI or DST overcomes CD8+ T-cell-mediated alloresistance to allogeneic marrow in recipients of anti-CD40L. Am J Transplant 4:31-40 (2004).
  • Blaha, P., Bigenzahn, S., Koporc, Z., Schmid, M., Langer, F., Selzer, E., Bergmeister, H., Wrba, F., Kurtz, J., Kiss, C., Roth, E., Muehlbacher, F., Sykes, M., and Wekerle, T. The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. Blood 101:2886-93 (2003).
  • Wekerle, T., Nikolic, B., Pearson, D. A., Swenson, K. G., and Sykes, M. Minimal conditioning required in a murine model of T cell depletion, thymic irradiation and high-dose bone marrow transplantation for the induction of mixed chimerism and tolerance. Transpl Int 15:248-53 (2002).
  • Kurtz, J., Ito, H., Wekerle, T., Shaffer, J., and Sykes, M. Mechanisms involved in the establishment of tolerance through costimulatory blockade and BMT: Lack of requirement for CD40L-mediated signaling for tolerance or deletion of donor-reactive CD4+ cells. Am J Transplant 1:339-49 (2001).
  • Wekerle, T., Kurtz, J., Sayegh, M. H., Ito, H., Wells, A. D., Bensinger, S., Shaffer, J., Turka, L. A., and Sykes, M. Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death. J Immunol 166:2311-6 (2001).
  • Zhao, Y., Swenson, K., Wekerle, T., Rodriguez-Barbosa, J. I., Arn, J. S., and Sykes, M. The critical role of mouse CD4+ cells in the rejection of highly disparate xenogeneic pig thymus grafts. Xenotransplantation 7:129-37 (2000).
  • Wekerle, T., Kurtz, J., Ito, H., Ronquillo, J. V., Dong, V., Zhao, G., Shaffer, J., Sayegh, M. H., and Sykes, M. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nature Med 6:464-9 (2000).

Review articles, book chapters and editorials:

  • Pilat, N., Hock, K., and Wekerle, T. Mixed chimerism through donor bone marrow transplantation – tolerogenic cell therapy for application in organ transplantation. Curr Opin Organ Transplant (invited – submitted) (2012).
  • Pilat, N., Sayegh, M. H., and Wekerle, T. Co-stimulatory pathways in transplantation. Sem Immunol (published online) (2011).
  • Baranyi, U., Gattringer, M., Valenta, R., and Wekerle, T. Cell-based therapy in allergy. Curr Top Microbiol Immunol 352:161-179 (2011).
  • Muehlbacher, F. and Wekerle, T.  Continuous improvement. Transpl Int 24:1 (editorial) (2011).
  • Pilat, N. and Wekerle, T. Mechanistic and therapeutic role of regulatory T cells in tolerance through mixed chimerism. Curr Opin Organ Transplant 15:725-30 (2010).
  • Pilat, N. and Wekerle, T. Transplantation tolerance through mixed chimerism. Nature Rev Nephrol 6:594-605 (2010).
  • Pilat, N. and Wekerle, T. Combining Treg therapy with mixed chimerism: getting the best of both worlds. Chimerism 1:26-9 (2010).
  • Wekerle, T. Surgical research – quo vadis? Eur Surg 42:111 (editorial) (2010).
  • Muehlbacher, F. and Wekerle, T.  Visible Progress. Transpl Int 23:1 (editorial) (2010).
  • Baranyi, U., Pilat, N., Gattringer, M., and Wekerle, T. A chimerism-based approach to induce tolerance in IgE-mediated allergy. Crit Rev Immunol 29:379-97 (2009).
  • Dahlke, M. H., Hoogduijn, M.,  Eggenhofer, E., Popp, F. C., Renner, P., Slowik, P., Rosenauer, A., Piso, P., Geissler, E, Lange, C., Chabannes, D., Mazzanti, B., Bigenzahn, S., Bertolino, P., Kunter, U., Introna, M., Rambaldi, A., Capelli, C., Perico, N., Casiraghi, F., Noris, M., Gotti, E., Seifert, M., Saccardi, R., Verspaget, H. W., van Hoek, B., Bartholomew, A., Wekerle, T., Volk, H. D., Remuzzi, G., Deans, R., Lazarus, H., Schlitt, H. J., and Baan, C. C. Toward MSC in solid organ transplantation: 2008 position paper of the MISOT Study Group. Transplantation 88:614-9 (2009).
  • Muller, Y. D., Golshayan, D.,  Ehirchiou, D., Wekerle, T., Seebach, J. D., and Buhler, L. H. T regulatory cells in xenotransplantation. Xenotransplantation 16:121-8 (2009).
  • Pilat, N., Klaus, C., Schwaiger, E., and Wekerle, T. Hurdles to the induction of tolerogenic mixed chimerism. Transplantation 87:S79-S84 (2009).
  • Pree, I., Pilat, N., and Wekerle, T. Bone marrow transplantation as a strategy for tolerance inductionin the clinic. Front Biosci 14:611-20 (2009).
  • Muehlbacher, F. and Wekerle, T.  Raising the benchmark. Transpl Int 22:143 (2009).
  • Wekerle, T. T regulatory cells – what relationship with immunosuppressive agents? Transplant Proc 40:S13-S16 (2008).
  • Muehlbacher, F. and Wekerle, T.  Next level. Transpl Int 21:1 (editorial) (2008).
  • Bodingbauer, M., Kramar, R., Wekerle, T., Boehmig, G., Berlakovich, G., Saemann, M., Steininger, R., Perco, P., Oberbauer, R., Hoerl, W., and Muehlbacher, F. Present status at the Vienna transplantation center after four thousand renal transplantations. Clin Transpl :69-80 (2007).
  • Pree, I., Pilat, N., and Wekerle, T. Recent progress in tolerance induction through mixed chimerism. Int Arch Allergy Immunol 144:254-66 (2007).
  • Hainz, U., Jurgens, B., Seidel, M. G., Wekerle, T., and Heitger, A. Indoleamine 2,3-dioxygenase in hematopoietic stem cell transplantation. Curr Drug Metab 8:267-72 (2007).
  • Pree, I. and Wekerle, T. Inducing mixed chimerism and transplantation tolerance through allogeneic bone marrow transplantation with costimulation blockade. Methods in molecular biology 380:391-403 (2007).
  • Muehlbacher, F. and Wekerle, T.  On course. Transpl Int 20:1 (editorial) (2007).
  • Pree, I. and Wekerle, T. New approaches to prevent transplant rejection: Costimulation blockers anti-CD40L and CTLA4Ig. Drug Discovery Today: Therapeutic Strategies 3:41-7 (2006).
  • Muehlbacher, F. and Wekerle, T.  Full speed ahead. Transpl Int 19:1 (Editorial) (2006).
  • Muehlbacher, F. and Wekerle, T.  Transplant International adopts the policy of a uniform clinical trial registration. Transpl Int 18:893 (Editorial) (2005).
  • Muehlbacher, F. and Wekerle, T.  Off to new horizons. Transpl Int 18:1 (Editorial) (2005).
  • Kurtz, J., Wekerle, T., and Sykes, M. Tolerance in mixed chimerism – a role for regulatory cells? Trends Immunol 25:518-23 (2004).
  • Heitger, A., Blaha, P., Bigenzahn, S., Muehlbacher, F., and Wekerle, T. The influence of immunosuppressive drugs on cell-induced graft tolerance. Curr Opin Organ Transplant 9:307-13 (2004).
  • Saemann, M. D., Zeyda, M., Stulnig, T., Böhmig, G. A., Wekerle, T., Hörl, W. H., and Zlabinger, G. Janus kinase-3 (JAK3) inhibition: a new immunosuppressive modality for allogeneic transplantation. Transpl Int 17:481-9 (2004).
  • Saemann, M., Muehlbacher, F., Zlabinger, G., and Wekerle, T. Selected commentary to: Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Europ Surgery 36:205-6 (2004).
  • Wekerle, T. and Sykes, M. Induction of tolerance. Surgery 135:359-64 (2004).
  • Muehlbacher, F. and Wekerle, T.  Changes, achievements, and improvements. Transpl Int 16:65 (Editorial) (2003).
  • Wekerle, T., Blaha, P., Koporc, Z., Bigenzahn, S., Pusch, M., and Muehlbacher, F. Mechanisms of tolerance induction through the transplantation of donor hematopoietic stem cells: central versus peripheral. Transplantation 75:21S-5S (2003).
  • Wekerle, T., Kurtz, J., Bigenzahn, S., Takeuchi, Y., and Sykes, M. Mechanisms of transplant tolerance induction using costimulatory blockade. Curr Opin Immunol 14:592-600 (2002).
  • Wekerle, T., Blaha, P., Langer, F., Schmid, M., and Muehlbacher, F. Tolerance through bone marrow transplantation with costimulation blockade. Transpl Immunol 9:125-33 (2002).
  • Wekerle, T., Blaha, P., Asari, R., Schmid, M., Kiss, C., Roth, E., and Mühlbacher, F. Tolerance induction through mixed chimerism. Europ Surgery 34:131-5 (2002).
  • T. Wekerle, C. Kiss, M. Bodingbauer, F. Langer, in Tacrolimus in der Herz- und Lungentransplantation, B. Reichart, Ed. (Pabst Science Publishers, 2001).
  • T. Wekerle, J. Kurtz, M. Sykes, in Cardiac Allograft Rejection, G. W. Dec, J. Narula, M. Ballester, Carrió, Eds. (Kluwer Academic Publishers, 2001).
  • Wekerle, T. Transplantation tolerance induced by mixed chimerism. J Heart Lung Transplant 20:816-23 (2001).
  • Wekerle, T. and Sykes, M. Mixed chimerism and transplantation tolerance. Annu Rev Med 52:353-70 (2001).

Patent:

  • Co-inventor of patent application no. WO 2008/148831